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Stages of chronic lymphocytic leukemia (CLL)

Staging of CLL helps determine the right treatment plan.

If you are diagnosed with CLL, your healthcare team will need to determine how advanced the disease is. This process is called staging. Doctors use a system called the RAI classification to determine the risk. Knowing the stage of the disease helps your healthcare team determine the correct treatment plan.

The 5 stages of chronic lymphocytic leukemia (CLL)

Stage 0

Stage 0 CLL.

Patients are at low risk and have lymphocytosis, an increase in the number of lymphocytes. A high lymphocyte count is defined as more than 10,000 lymphocytes per cubic millimeter

The 5 stages of chronic lymphocytic leukemia (CLL)

Stage I

Stage I CLL.

Patients are at intermediate risk and have lymphocytosis, plus enlarged lymph nodes

The 5 stages of chronic lymphocytic leukemia (CLL)

Stage II

Stage II CLL.

Patients are at intermediate risk but have lymphocytosis plus an enlarged liver or enlarged spleen, with or without lymphadenopathy

The 5 stages of chronic lymphocytic leukemia (CLL)

Stage III

Stage III CLL.

Patients are at high risk and have lymphocytosis plus anemia

The 5 stages of chronic lymphocytic leukemia (CLL)

Stage IV

Stage IV CLL.

Patients are at high risk but have lymphocytosis plus thrombocytopenia, a low number of blood platelets

Learn about risk factors of CLL

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US.XON.10.04.015 Last Update: May 2010